MKX

Across TCGA patient cohorts, MKX mutation is significantly associated with the RNA expression of many other genes, with 2,830 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MKX-associated genes across cancer lineages are DR1, KCTD9, and GOT1. Each is linked with MKX in more than 2 cancer types. Because this analysis shows association rather than direction, both MKX-to-partner and partner-to-MKX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DR1 grouped by MKX-low versus MKX-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKX→partner) and Y-score (partner→MKX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DR1 →	+0.494	+2.247	.007	.005	3	3
UCEC	KCTD9 →	+0.599	+2.436	<.001	.001	3	3
UCEC	GOT1 →	+0.333	+2.950	.005	<.001	3	3
UCEC	ZWINT →	+0.736	+2.700	<.001	<.001	3	3
UCEC	PPAT →	+0.639	+2.000	<.001	.001	3	3
UCEC	PSMC3IP →	+0.604	+2.828	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,830 associations by consensus.

DR1 by MKX expression — SKCM

Explore this box plot interactively →