MKX

Across TCGA patient cohorts, MKX mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MKX-associated genes across cancer lineages are Ku80, JNK_pT183_Y185, and PDCD4. Each is linked with MKX in more than 2 cancer types. Because this analysis shows association rather than direction, both MKX-to-partner and partner-to-MKX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by MKX-low versus MKX-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKX→partner) and Y-score (partner→MKX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Ku80 →	+0.310	+3.169	.009	.017	3	3
UCEC	JNK_pT183_Y185 →	-0.163	-2.321	.006	.005	3	2
UCEC	PDCD4 →	-0.509	-2.000	.002	.029	3	2
UCEC	Smad3 →	+0.128	+2.115	.016	.017	3	2
UCEC	Caspase-8 →	-0.249	-3.780	.005	<.001	3	2
UCEC	cIAP →	+0.095	+2.594	.049	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Ku80 by MKX expression — SKCM

Explore this box plot interactively →