MKX

Across TCGA cell cohorts, MKX RNA expression is significantly associated with the go_rna of many other GO terms, with 1,611 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MKX-associated GO terms across cancer lineages are Negative regulation of post-translational protein modification, Translational initiation, and RNA splicing, via transesterification reactions. Each is linked with MKX in more than 7 cancer types. Because this analysis shows association rather than direction, both MKX-to-partner and partner-to-MKX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of post-translational protein modification grouped by MKX-low versus MKX-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MKX→partner) and Y-score (partner→MKX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of post-translational protein modification →	+0.055	+0.766	.007	.005	3	8
OESOPHAGUS	Translational initiation →	+0.115	+1.281	.001	.001	3	8
OESOPHAGUS	RNA splicing, via transesterification reactions →	+0.068	+0.908	<.001	<.001	3	7
OESOPHAGUS	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.066	+0.908	<.001	<.001	3	7
OESOPHAGUS	mRNA splicing, via spliceosome →	+0.066	+0.908	<.001	<.001	3	7
OESOPHAGUS	mRNA catabolic process →	+0.049	+0.768	.003	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,611 associations by consensus.

Negative regulation of post-translational protein modification by MKX expression — OESOPHAGUS

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