MKX

Across TCGA cell cohorts, MKX mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MKX-associated genes across cancer lineages are PRAMEF14, C2orf80, and FCGR2B. Each is linked with MKX in more than 1 cancer types. Because this analysis shows association rather than direction, both MKX-to-partner and partner-to-MKX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF14 grouped by MKX-low versus MKX-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKX→partner) and Y-score (partner→MKX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRAMEF14 →	+0.013	+4.906	<.001	.006	3	1
LARGE_INTESTINE	C2orf80 →	+0.024	+3.632	<.001	.003	3	1
LARGE_INTESTINE	FCGR2B →	+0.157	+3.453	<.001	.009	3	1
BLOOD_Leukemia	LYZL4 →	+0.070	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OR1N2 →	+0.044	+4.705	<.001	.003	3	1
BLOOD_Leukemia	REC114 →	+0.088	+4.409	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PRAMEF14 by MKX expression — OESOPHAGUS

Explore this box plot interactively →