makorin ring finger protein 8, pseudogeneGenealiases: MKRNP4 · ZNF127L4
Q-omics provides the consensus-scored MKRN8P profile across patient tissues and cancer cell-line models. MKRN8P expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, MKRN8P is differentially expressed in 6, with the highest sampling consensus in HNSC. Additionally, MKRN8P RNA expression shows 8,377 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KICH, HNSC, and LSCC as cancer lineages where MKRN8P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MKRN8P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MKRN8P survival associations across molecular data types. MKRN8P RNA expression shows survival associations in the most cancer types (17). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MKRN8P RNA expression–survival associations across cancer types. High MKRN8P expression shows unfavorable associations in KICH, ACC, UCEC, KIRC and UVM, but favorable associations in LUSC. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KICH as the clearest survival context for MKRN8P RNA expression.
This table summarizes MKRN8P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for MKRN8P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MKRN8P shows higher tumor expression in HNSC, BRCA, LUSC, LUAD, KICH and KIRC. The HNSC box plot shows higher MKRN8P RNA expression in tumor versus normal tissue (log2 FC = +0.126, t-test p < 0.001).
This table shows molecular features associated with MKRN8P in patient tissues and cancer cell lines. In patient samples, MKRN8P shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
