Across TCGA pan-cancer cohorts, MKRN6P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MKRN6P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MKRN6P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MKRN6P is over-expressed in tumor, although a few such as BRCA and COAD show the opposite, repressed pattern.

HNSC, BRCA, and KIRP are the cancer types where MKRN6P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MKRN6P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.625	<.001	12	view →
BRCA	Female	All	−0.248	<.001	6	view →
KIRP	Female	All	+0.258	.025	1	view →
COAD	Female	All	−0.082	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: MKRN6P RNA expression & survival · all MKRN6P data types