Across TCGA pan-cancer cohorts, MKRN2OS RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MKRN2OS data layer.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MKRN2OS RNA is associated with better overall survival. In most high-consensus cancer types, elevated MKRN2OS expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.
UCEC, BLCA, and SCLC are the cancer types where MKRN2OS RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.