MKRN2

Across TCGA patient cohorts, MKRN2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MKRN2-associated genes across cancer lineages are ATM, A-Raf_pS299, and ERK2. Each is linked with MKRN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MKRN2-to-partner and partner-to-MKRN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MKRN2-low versus MKRN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKRN2→partner) and Y-score (partner→MKRN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.677	-2.222	<.001	.011	3	2
UCEC	A-Raf_pS299 →	-0.176	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.213	+1.700	.009	.044	3	1
UCEC	Gab2 →	+0.492	+3.321	.001	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.170	-2.209	.017	.011	3	1
UCEC	JNK2 →	+0.300	+2.348	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by MKRN2 expression — UCEC

Explore this box plot interactively →