MKRN2

Across TCGA cell cohorts, MKRN2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MKRN2-associated genes across cancer lineages are LACRT, AVP, and FCGR3B. Each is linked with MKRN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MKRN2-to-partner and partner-to-MKRN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LACRT grouped by MKRN2-low versus MKRN2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKRN2→partner) and Y-score (partner→MKRN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LACRT →	+0.278	+4.981	<.001	.008	3	1
LARGE_INTESTINE	AVP →	+0.085	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	FCGR3B →	+0.174	+4.467	<.001	.004	3	1
LARGE_INTESTINE	SCGB3A2 →	+0.394	+4.095	<.001	.009	3	1
LARGE_INTESTINE	OR2B3 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CELA2B →	+0.084	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

LACRT by MKRN2 expression — CNS

Explore this box plot interactively →