MKRN2

Across TCGA cell cohorts, MKRN2 mutation is significantly associated with the mutation status of many other genes, with 2,149 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MKRN2-associated genes across cancer lineages are FLCN, CCDC73, and DDX60L. Each is linked with MKRN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MKRN2-to-partner and partner-to-MKRN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FLCN grouped by MKRN2-low versus MKRN2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKRN2→partner) and Y-score (partner→MKRN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FLCN →	+6.044	+6.044	.001	.001	1	4
STOMACH	CCDC73 →	+4.807	+4.807	.008	.008	1	4
OVARY	DDX60L →	+4.415	+4.977	.007	.007	1	4
STOMACH	MVP →	+4.807	+4.807	.008	.008	1	3
STOMACH	AGK →	+4.807	+4.807	.008	.008	1	3
LARGE_INTESTINE	CNTN1 →	+2.611	+4.372	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,149 associations by consensus.

FLCN by MKRN2 expression — CNS

Explore this box plot interactively →