MKRN1

Across TCGA pan-cancer cohorts, MKRN1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MKRN1 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MKRN1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MKRN1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

CCRCC, UCEC, and LSCC are the cancer types where MKRN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.890	1.000	.004	43	view →
UCEC	DFS	Quartile	All	0.965	0.807	.029	10	view →
LSCC	DFS	Median	All	0.883	0.699	.015	7	view →
LUAD	OS	Tertile	III,IV	0.638	0.311	.028	5	view →
GBM	OS	Tertile	All	0.578	0.932	.010	4	view →
HNSC	DFS	Quartile	All	1.000	0.943	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MKRN1–CCRCC (OS)

Open the CCRCC breakdown →