MKRN1

Across TCGA cell cohorts, MKRN1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MKRN1-associated genes across cancer lineages are MMP26, TPD52L3, and C10orf53. Each is linked with MKRN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MKRN1-to-partner and partner-to-MKRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by MKRN1-low versus MKRN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKRN1→partner) and Y-score (partner→MKRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MMP26 →	+0.048	+4.217	<.001	.001	3	1
LARGE_INTESTINE	TPD52L3 →	+0.044	+3.684	<.001	.006	3	1
LARGE_INTESTINE	C10orf53 →	+0.019	+4.217	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MMP26 by MKRN1 expression — LARGE_INTESTINE

Explore this box plot interactively →