MKNK2

Across TCGA patient cohorts, MKNK2 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,585 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MKNK2-associated proteins across cancer lineages are EIF4G1_S1238, MKNK2_S220, and THOP1. Each is linked with MKNK2 in more than 5 cancer types. Because this analysis shows association rather than direction, both MKNK2-to-partner and partner-to-MKNK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MKNK2 versus EIF4G1_S1238 in LSCC, with a Pearson correlation of 0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MKNK2→partner) and Y-score (partner→MKNK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EIF4G1_S1238 →	+0.712	+0.767	<.001	<.001	3	6
BRCA	MKNK2_S220 →	+0.971	+1.162	<.001	<.001	3	6
OV	THOP1 →	+0.392	+0.733	.001	<.001	3	5
LSCC	CAMSAP3 →	+0.559	+0.697	<.001	<.001	3	5
GBM	CLPP →	+0.274	+0.512	.003	<.001	3	5
LSCC	PTBP2 →	-1.046	-0.685	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,585 associations by consensus.

MKNK2 vs EIF4G1_S1238 — LSCC

Explore this scatter interactively →