MKNK2

Across TCGA patient cohorts, MKNK2 mutation is significantly associated with the RNA expression of many other genes, with 770 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MKNK2-associated genes across cancer lineages are ZIK1P1, RN7SL156P, and MIR548U. Each is linked with MKNK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MKNK2-to-partner and partner-to-MKNK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIK1P1 grouped by MKNK2-low versus MKNK2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKNK2→partner) and Y-score (partner→MKNK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZIK1P1 →	+0.039	+4.990	<.001	.009	3	2
LUAD	RN7SL156P →	+0.201	+5.888	<.001	.002	3	2
UCEC	MIR548U →	+0.547	+2.912	<.001	.009	3	2
UCEC	MTND5P26 →	+0.282	+2.230	<.001	.005	3	2
CESC	ARHGAP42P4 →	+0.012	+5.418	<.001	.005	3	2
BRCA	RNU6-1028P →	+0.643	+6.268	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 770 associations by consensus.

ZIK1P1 by MKNK2 expression — LUAD

Explore this box plot interactively →