MKNK2

Across TCGA cell cohorts, MKNK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,513 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MKNK2-associated GO terms across cancer lineages are Circadian regulation of gene expression, Protein poly-ADP-ribosylation, and Cilium or flagellum-dependent cell motility. Each is linked with MKNK2 in more than 9 cancer types. Because this analysis shows association rather than direction, both MKNK2-to-partner and partner-to-MKNK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Circadian regulation of gene expression grouped by MKNK2-low versus MKNK2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MKNK2→partner) and Y-score (partner→MKNK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Circadian regulation of gene expression →	+0.112	+1.245	<.001	<.001	3	10
LARGE_INTESTINE	Protein poly-ADP-ribosylation →	+0.109	+0.807	<.001	.002	3	10
SOFT_TISSUE	Cilium or flagellum-dependent cell motility →	-0.088	-1.225	<.001	<.001	3	8
BONE	Transcription pausing by RNA polymerase II →	+0.142	+0.825	.001	.001	3	8
SOFT_TISSUE	Flagellated sperm motility →	-0.098	-1.334	<.001	<.001	3	8
SOFT_TISSUE	Cilium-dependent cell motility →	-0.088	-1.225	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,513 associations by consensus.

Circadian regulation of gene expression by MKNK2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →