MKNK2

Across TCGA cell cohorts, MKNK2 mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MKNK2-associated genes across cancer lineages are PRAMEF8, TRIM64B, and WDR87. Each is linked with MKNK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MKNK2-to-partner and partner-to-MKNK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF8 grouped by MKNK2-low versus MKNK2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKNK2→partner) and Y-score (partner→MKNK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRAMEF8 →	+0.022	+3.584	.001	.004	3	2
BLOOD_Lymphoma	TRIM64B →	+0.030	+3.342	<.001	.008	3	2
BLOOD_Leukemia	WDR87 →	+0.024	+3.280	<.001	.009	3	2
BLOOD_Leukemia	FBXW10 →	+0.054	+3.938	<.001	.002	3	2
BLOOD_Myeloma	IFNA5 →	+0.027	+3.906	<.001	.009	3	1
BLOOD_Myeloma	OR10Z1 →	+0.018	+4.285	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

PRAMEF8 by MKNK2 expression — BLOOD_Lymphoma

Explore this box plot interactively →