MKNK1

Across TCGA patient cohorts, MKNK1 mutation is significantly associated with the RNA expression of many other genes, with 2,087 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MKNK1-associated genes across cancer lineages are SNORD126, LINC02719, and ABALON. Each is linked with MKNK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MKNK1-to-partner and partner-to-MKNK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD126 grouped by MKNK1-low versus MKNK1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKNK1→partner) and Y-score (partner→MKNK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SNORD126 →	+0.619	+3.996	<.001	.005	3	3
GBM	LINC02719 →	+0.174	+5.352	<.001	.005	3	2
UCEC	ABALON →	+0.376	+1.958	.006	.003	3	2
UCEC	APIP →	+0.421	+2.708	.006	.003	3	2
UCEC	EIF4E →	+0.425	+1.979	.001	.002	3	2
UCEC	NR3C2 →	+0.571	+2.008	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,087 associations by consensus.

SNORD126 by MKNK1 expression — CESC

Explore this box plot interactively →