MKNK1

Across TCGA patient cohorts, MKNK1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MKNK1-associated genes across cancer lineages are Notch1, PCNA, and ER-alpha_pS118. Each is linked with MKNK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MKNK1-to-partner and partner-to-MKNK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MKNK1-low versus MKNK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKNK1→partner) and Y-score (partner→MKNK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.158	+3.331	.006	.005	3	2
UCEC	PCNA →	+0.228	+1.807	.010	.027	3	2
UCEC	ER-alpha_pS118 →	-0.400	-2.584	.006	.010	3	1
UCEC	PDCD4 →	-0.725	-2.690	<.001	.006	3	1
UCEC	PKC-a →	+0.403	+2.321	.015	.006	3	1
UCEC	AMPK_pT172 →	+0.365	+2.321	.031	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Notch1 by MKNK1 expression — UCEC

Explore this box plot interactively →