MKNK1

Across TCGA cell cohorts, MKNK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,833 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MKNK1-associated GO terms across cancer lineages are Endosomal transport, Protein targeting, and Phospholipid biosynthetic process. Each is linked with MKNK1 in more than 12 cancer types. Because this analysis shows association rather than direction, both MKNK1-to-partner and partner-to-MKNK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal transport grouped by MKNK1-low versus MKNK1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MKNK1→partner) and Y-score (partner→MKNK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Endosomal transport →	+0.050	+1.103	.005	<.001	3	13
BLOOD_Myeloma	Protein targeting →	+0.046	+0.857	.004	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Phospholipid biosynthetic process →	+0.045	+0.895	<.001	.001	3	12
LIVER	Cytosolic transport →	+0.063	+0.557	.002	.005	3	11
LARGE_INTESTINE	Negative regulation of transcription initiation by RNA polymerase II →	+0.132	+0.585	<.001	.001	3	10
BLOOD_Lymphoma	Regulation of translational initiation →	+0.058	+0.612	.002	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,833 associations by consensus.

Endosomal transport by MKNK1 expression — URINARY_TRACT

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