MKNK1

Across TCGA cell cohorts, MKNK1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MKNK1-associated genes across cancer lineages are FAM236A, TAAR8, and CT47A1. Each is linked with MKNK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MKNK1-to-partner and partner-to-MKNK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM236A grouped by MKNK1-low versus MKNK1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKNK1→partner) and Y-score (partner→MKNK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.120	+5.357	<.001	.003	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.019	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	CT47A1 →	+0.046	+6.266	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

FAM236A by MKNK1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →