MKLN1

Across TCGA patient cohorts, MKLN1 mutation is significantly associated with the RNA expression of many other genes, with 3,266 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MKLN1-associated genes across cancer lineages are RPL26P31, YWHAQP1, and MIR4797. Each is linked with MKLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MKLN1-to-partner and partner-to-MKLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL26P31 grouped by MKLN1-low versus MKLN1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKLN1→partner) and Y-score (partner→MKLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RPL26P31 →	+0.179	+4.341	<.001	.007	3	2
READ	YWHAQP1 →	+0.160	+4.672	<.001	.004	3	2
READ	MIR4797 →	+0.640	+4.054	<.001	.004	3	2
READ	FXYD6P1 →	+0.175	+4.672	<.001	.004	3	2
UCEC	TMEM138 →	+0.203	+2.416	.005	<.001	3	2
UCEC	C18orf25 →	+0.408	+2.513	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,266 associations by consensus.

RPL26P31 by MKLN1 expression — READ

Explore this box plot interactively →