MKLN1

Across TCGA patient cohorts, MKLN1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MKLN1-associated genes across cancer lineages are p62 Lck ligand, 4E-BP1, and 14-3-3_beta. Each is linked with MKLN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MKLN1-to-partner and partner-to-MKLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by MKLN1-low versus MKLN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKLN1→partner) and Y-score (partner→MKLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.345	+1.938	.001	.001	3	3
UCEC	4E-BP1 →	+0.283	+2.459	.001	.018	3	3
UCEC	14-3-3_beta →	-0.072	-3.558	.029	.002	3	2
UCEC	eIF4E →	+0.170	+1.652	.014	.006	3	2
UCEC	ERK2 →	+0.214	+2.502	<.001	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.153	-1.765	.005	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

p62 Lck ligand by MKLN1 expression — UCEC

Explore this box plot interactively →