MKLN1

Across TCGA cell cohorts, MKLN1 mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MKLN1-associated genes across cancer lineages are OXT, C6orf118, and CR2. Each is linked with MKLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MKLN1-to-partner and partner-to-MKLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by MKLN1-low versus MKLN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKLN1→partner) and Y-score (partner→MKLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OXT →	+0.354	+2.688	<.001	.002	3	1
LARGE_INTESTINE	C6orf118 →	+0.124	+3.015	<.001	<.001	3	1
LARGE_INTESTINE	CR2 →	+0.680	+3.354	.001	.003	3	1
LARGE_INTESTINE	CUTC →	+0.626	+3.064	.002	.009	3	1
LARGE_INTESTINE	RAB3IP →	+0.713	+3.385	.001	.004	3	1
LARGE_INTESTINE	ULBP2 →	+1.160	+3.212	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

OXT by MKLN1 expression — LARGE_INTESTINE

Explore this box plot interactively →