MKI67

Across TCGA pan-cancer cohorts, MKI67 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated MKI67 data layer compared with 28 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MKI67 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated MKI67 expression acts as an unfavorable survival marker, although some lineages such as UCEC and ESCA show a favorable association.

UCEC, KIRP, and LIHC are the cancer types where MKI67 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.778	0.617	<.001	36	view →
KIRP	DFS	Median	All	0.176	0.829	<.001	18	view →
LIHC	OS	Median	All	0.079	0.774	<.001	18	view →
COAD	OS	Median	IV	0.098	0.658	<.001	18	view →
LUSC	DFS	Median	II,III,IV	0.159	0.784	<.001	16	view →
CHOL	DFS	Median	All	0.045	0.486	.009	15	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
ESCA	OS	Median	III,IV	1.000	0.507	.008	12	view →
LGG	OS	Median	All	0.103	0.890	<.001	6	view →
BLCA	OS	Median	III,IV	0.671	0.340	.015	6	view →
ACC	OS	Median	All	0.149	0.686	.047	3	view →
HNSC	OS	Median	III,IV	0.894	0.310	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

MKI67–UCEC (DFS)

Open the UCEC breakdown →