MKI67

Across TCGA pan-cancer cohorts, MKI67 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MKI67 data layer compared with 28 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MKI67 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MKI67 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

COAD, CCRCC, and LSCC are the cancer types where MKI67 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.918	1.000	.011	24	view →
CCRCC	DFS	Quartile	III,IV	0.188	0.793	.008	8	view →
LSCC	OS	Median	II,III,IV	0.885	0.601	.009	7	view →
LUAD	OS	Tertile	II,III,IV	0.323	0.893	.020	5	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	3	view →
HNSC	OS	Median	All	0.806	0.900	.025	2	view →
UCEC	DFS	Median	All	0.788	0.918	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MKI67–COAD (DFS)

Open the COAD breakdown →