Across TCGA patient cohorts, MIXL1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIXL1-associated genes across cancer lineages are MIR6738, MIR6090, and OR52X1P. Each is linked with MIXL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIXL1-to-partner and partner-to-MIXL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIXL1→partner) and Y-score (partner→MIXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6738 →	+0.618	+3.041	.001	.008	3	1
SKCM	MIR6090 →	+0.671	+5.159	<.001	.007	3	1
SKCM	OR52X1P →	+0.060	+5.097	<.001	.008	3	1
SKCM	RN7SL649P →	+0.332	+5.224	<.001	.007	3	1
UCEC	MIR6775 →	+0.624	+3.756	.001	.001	3	1
UCEC	MIA-RAB4B →	+0.120	+4.448	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

MIXL1 survival (RNA) · tumor vs normal (RNA) · all MIXL1 data types