Across TCGA cell cohorts, MIXL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,438 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MIXL1-associated GO terms across cancer lineages are RNA splicing, via transesterification reactions, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, and mRNA splicing, via spliceosome. Each is linked with MIXL1 in more than 7 cancer types. Because this analysis shows association rather than direction, both MIXL1-to-partner and partner-to-MIXL1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIXL1→partner) and Y-score (partner→MIXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNA splicing, via transesterification reactions →	+0.055	+0.271	<.001	<.001	3	8
BONE	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.056	+0.271	<.001	<.001	3	8
BONE	mRNA splicing, via spliceosome →	+0.056	+0.271	<.001	<.001	3	8
PANCREAS	Cytoplasmic translation →	+0.059	+0.069	.005	.007	2	8
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.048	+0.055	.009	.006	3	7
BONE	Cell cycle phase transition →	+0.070	+0.274	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,438 associations by consensus.

Exploration

MIXL1 survival (RNA) · tumor vs normal (RNA) · all MIXL1 data types