Across TCGA patient cohorts, MITF protein abundance is significantly associated with the RNA expression of many other genes, with 9,583 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MITF-associated genes across cancer lineages are RN7SL418P, PCOLCE, and BST1. Each is linked with MITF in more than 6 cancer types. Because this analysis shows association rather than direction, both MITF-to-partner and partner-to-MITF results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MITF→partner) and Y-score (partner→MITF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL418P →	+1.285	+0.706	<.001	<.001	3	7
BRCA	PCOLCE →	+1.258	+0.466	<.001	<.001	3	6
COAD	BST1 →	+1.062	+0.484	.002	.002	3	6
COAD	DSE →	+1.342	+0.690	.001	<.001	3	6
COAD	EDIL3 →	+1.752	+0.700	.004	<.001	3	6
COAD	FBN1 →	+1.705	+0.752	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,583 associations by consensus.

Exploration

MITF survival (RNA) · tumor vs normal (RNA) · all MITF data types