Across TCGA patient cohorts, MITF mutation is significantly associated with the RNA expression of many other genes, with 3,479 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MITF-associated genes across cancer lineages are BNIP3P41, FAM98B, and GPHN. Each is linked with MITF in more than 2 cancer types. Because this analysis shows association rather than direction, both MITF-to-partner and partner-to-MITF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MITF→partner) and Y-score (partner→MITF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BNIP3P41 →	+0.008	+3.734	.002	.009	3	3
UCEC	FAM98B →	+0.319	+1.409	.008	.002	3	3
UCEC	GPHN →	+0.393	+3.616	.001	.001	3	3
UCEC	TIMM21 →	+0.400	+1.794	<.001	<.001	3	3
UCEC	WDR76 →	+0.709	+2.258	<.001	<.001	3	3
UCEC	TUBGCP5 →	+0.342	+1.430	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,479 associations by consensus.

Exploration

MITF survival (RNA) · tumor vs normal (RNA) · all MITF data types