Across TCGA patient cohorts, MITF mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MITF-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and PDCD4. Each is linked with MITF in more than 3 cancer types. Because this analysis shows association rather than direction, both MITF-to-partner and partner-to-MITF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MITF→partner) and Y-score (partner→MITF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.134	+1.353	.002	.015	3	4
COAD	Caspase-7-cleavedD198 →	+0.789	+1.708	.008	.026	3	3
COAD	PDCD4 →	-0.422	-3.000	.008	.035	3	2
COAD	Smad4 →	+0.112	+3.169	.027	.017	3	2
UCEC	ATM →	-0.554	-2.489	<.001	.001	3	2
UCEC	eIF4E →	+0.216	+4.013	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Exploration

MITF survival (RNA) · tumor vs normal (RNA) · all MITF data types