Across TCGA cell cohorts, MITF mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MITF-associated genes across cancer lineages are PRR23C, NUPR2, and IQCF6. Each is linked with MITF in more than 1 cancer types. Because this analysis shows association rather than direction, both MITF-to-partner and partner-to-MITF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MITF→partner) and Y-score (partner→MITF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	1
LARGE_INTESTINE	NUPR2 →	+0.395	+4.273	<.001	.006	3	1
LARGE_INTESTINE	IQCF6 →	+0.322	+4.467	<.001	.004	3	1
LUNG_NSCLC_LUAD	PF4V1 →	+0.978	+4.215	<.001	.002	3	1
LUNG_NSCLC_LUAD	WFDC8 →	+0.017	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR51I2 →	+0.176	+3.977	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

MITF survival (RNA) · tumor vs normal (RNA) · all MITF data types