MITD1

Across TCGA patient cohorts, MITD1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MITD1-associated genes across cancer lineages are Ku80, STAT3_pY705, and Tuberin. Each is linked with MITD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MITD1-to-partner and partner-to-MITD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by MITD1-low versus MITD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MITD1→partner) and Y-score (partner→MITD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.256	+2.820	.048	.035	3	1
UCEC	STAT3_pY705 →	-0.494	-2.990	<.001	.036	3	1
UCEC	Tuberin →	+0.517	+3.009	<.001	.019	3	1
UCEC	Cyclin-B1 →	+0.774	+3.169	.011	.020	3	1
UCEC	MEK1 →	+0.469	+3.169	.019	.020	1	1
UCEC	Caspase-8 →	-0.289	-3.169	.036	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Ku80 by MITD1 expression — UCEC

Explore this box plot interactively →