MISP3

Across TCGA pan-cancer cohorts, MISP3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MISP3 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MISP3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MISP3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where MISP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.605	0.284	<.001	101	view →
HNSC	DFS	Quartile	All	0.916	0.334	.003	25	view →
CCRCC	OS	Median	All	1.000	0.667	.008	14	view →
LUAD	OS	Quartile	All	0.862	0.669	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MISP3–PDAC (DFS)

Open the PDAC breakdown →