MIS18BP1

Across TCGA pan-cancer cohorts, MIS18BP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MIS18BP1 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MIS18BP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MIS18BP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, UCEC, and PDAC are the cancer types where MIS18BP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.929	0.552	<.001	58	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.289	.020	28	view →
PDAC	DFS	Tertile	All	0.758	0.862	.013	5	view →
HNSC	DFS	Quartile	III,IV	0.320	0.764	.011	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MIS18BP1–LSCC (OS)

Open the LSCC breakdown →