MIS18BP1

Across TCGA patient cohorts, MIS18BP1 mutation is significantly associated with the RNA expression of many other genes, with 4,309 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIS18BP1-associated genes across cancer lineages are FCGR1A, SEC13, and HK3. Each is linked with MIS18BP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MIS18BP1-to-partner and partner-to-MIS18BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCGR1A grouped by MIS18BP1-low versus MIS18BP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIS18BP1→partner) and Y-score (partner→MIS18BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FCGR1A →	+0.482	+1.485	.001	.003	3	3
UCEC	SEC13 →	+0.474	+2.146	<.001	<.001	3	3
UCEC	HK3 →	+0.621	+2.094	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.834	+2.754	<.001	<.001	3	3
STAD	WDR41 →	+0.598	+3.203	<.001	.009	3	3
UCEC	ATPAF2 →	+0.398	+2.157	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,309 associations by consensus.

FCGR1A by MIS18BP1 expression — UCEC

Explore this box plot interactively →