MIS18BP1

Across TCGA patient cohorts, MIS18BP1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIS18BP1-associated genes across cancer lineages are 14-3-3_beta, eIF4G, and ACC1. Each is linked with MIS18BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIS18BP1-to-partner and partner-to-MIS18BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MIS18BP1-low versus MIS18BP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIS18BP1→partner) and Y-score (partner→MIS18BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.077	-1.651	.013	.019	3	2
UCEC	eIF4G →	+0.314	+2.999	.001	<.001	3	2
UCEC	ACC1 →	+0.266	+1.598	.018	.040	3	2
UCEC	p27 →	-0.142	-1.201	.036	.028	3	2
UCEC	S6_pS240_S244 →	+0.291	+1.415	.021	.010	3	2
UCEC	eIF4E →	+0.215	+2.169	.001	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

14-3-3_beta by MIS18BP1 expression — UCEC

Explore this box plot interactively →