MIS18BP1

Across TCGA cell cohorts, MIS18BP1 mutation is significantly associated with the RNA expression of many other genes, with 685 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MIS18BP1-associated genes across cancer lineages are CAPZA3, SSMEM1, and FCN2. Each is linked with MIS18BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIS18BP1-to-partner and partner-to-MIS18BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAPZA3 grouped by MIS18BP1-low versus MIS18BP1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIS18BP1→partner) and Y-score (partner→MIS18BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CAPZA3 →	+0.068	+4.196	<.001	.001	3	2
LARGE_INTESTINE	SSMEM1 →	+0.017	+1.930	.002	.007	3	2
BLOOD_Myeloma	FCN2 →	+0.060	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR1E1 →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR52E8 →	+0.030	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CLDN34 →	+0.043	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 685 associations by consensus.

CAPZA3 by MIS18BP1 expression — CNS

Explore this box plot interactively →