MIS12

Across TCGA pan-cancer cohorts, MIS12 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MIS12 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MIS12 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MIS12 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where MIS12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.631	0.908	.016	21	view →
PDAC	OS	Median	II,III,IV	0.755	0.920	.008	21	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.374	.024	6	view →
LUAD	DFS	Quartile	II,III,IV	0.597	0.277	.033	5	view →
CCRCC	DFS	Median	All	0.814	0.660	.045	2	view →
GBM	OS	Quartile	All	0.758	0.403	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MIS12–HNSC (DFS)

Open the HNSC breakdown →