MIS12

Across TCGA patient cohorts, MIS12 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIS12-associated genes across cancer lineages are eIF4G, FOXO3a_pS318_S321, and ACC_pS79. Each is linked with MIS12 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIS12-to-partner and partner-to-MIS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by MIS12-low versus MIS12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIS12→partner) and Y-score (partner→MIS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.414	+3.169	.005	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.148	-3.312	.014	.010	3	1
UCEC	ACC_pS79 →	+0.499	+3.009	.002	.019	3	1
UCEC	Heregulin →	-0.144	-2.459	.015	.020	3	1
UCEC	INPP4B →	-0.345	-2.446	.027	.020	3	1
UCEC	Ku80 →	+0.284	+3.009	.012	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eIF4G by MIS12 expression — UCEC

Explore this box plot interactively →