MIS12

Across TCGA cell cohorts, MIS12 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,677 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MIS12-associated GO terms across cancer lineages are Regulation of telomere maintenance via telomerase, Attachment of mitotic spindle microtubules to kinetochore, and Kinetochore organization. Each is linked with MIS12 in more than 15 cancer types. Because this analysis shows association rather than direction, both MIS12-to-partner and partner-to-MIS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomere maintenance via telomerase grouped by MIS12-low versus MIS12-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIS12→partner) and Y-score (partner→MIS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of telomere maintenance via telomerase →	+0.075	+0.790	<.001	<.001	3	16
SOFT_TISSUE	Attachment of mitotic spindle microtubules to kinetochore →	+0.148	+0.978	<.001	<.001	3	16
SOFT_TISSUE	Kinetochore organization →	+0.117	+0.612	<.001	<.001	3	15
SOFT_TISSUE	RNA-templated DNA biosynthetic process →	+0.093	+0.722	<.001	<.001	3	14
BONE	snRNA export from nucleus →	+0.151	+0.772	.001	.002	3	14
SOFT_TISSUE	Kinetochore assembly →	+0.115	+0.612	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,677 associations by consensus.

Regulation of telomere maintenance via telomerase by MIS12 expression — OVARY

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