Across TCGA pan-cancer cohorts, MIR887 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR887’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where MIR887 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR887 is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.
BRCA and UCEC are the cancer types where MIR887 tumor–normal differential expression is most reproducible.