Across TCGA pan-cancer cohorts, MIR8066 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR8066’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where MIR8066 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR8066 is over-expressed in tumor, although a few such as BRCA and LUSC show the opposite, repressed pattern.
BRCA and LUSC are the cancer types where MIR8066 tumor–normal differential expression is most reproducible.