Across TCGA pan-cancer cohorts, MIR6880 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR6880’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MIR6880 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR6880 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC are the cancer types where MIR6880 tumor–normal differential expression is most reproducible.