MIR6859-4

Across TCGA pan-cancer cohorts, MIR6859-4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MIR6859-4 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MIR6859-4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MIR6859-4 expression acts as an unfavorable survival marker, although some lineages such as LUSC and LUAD show a favorable association.

KIRC, CHOL, and ESCA are the cancer types where MIR6859-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.511	0.694	<.001	124	view →
CHOL	OS	Quartile	All	0.406	0.943	.003	42	view →
ESCA	OS	Tertile	III,IV	0.263	0.606	.006	40	view →
LUSC	OS	Quartile	All	0.976	0.760	<.001	39	view →
COAD	DFS	Tertile	All	0.531	0.727	.001	36	view →
ACC	OS	Quartile	All	0.527	0.883	<.001	30	view →
LUAD	DFS	Tertile	III,IV	0.808	0.565	.003	20	view →
OV	DFS	Median	IV	0.226	0.385	.012	20	view →
MESO	DFS	Quartile	IV	0.126	0.754	.001	15	view →
UCEC	DFS	Tertile	All	0.830	0.904	.011	12	view →
GBM	DFS	Median	All	0.371	0.197	.019	9	view →
READ	DFS	Tertile	III,IV	0.325	0.693	.031	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MIR6859-4–KIRC (DFS)

Open the KIRC breakdown →