MIR6858

Across TCGA patient cohorts, MIR6858 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,060 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIR6858-associated GO terms across cancer lineages are Negative regulation of protein K63-linked ubiquitination, Protein localization to presynapse, and rRNA base methylation. Each is linked with MIR6858 in more than 7 cancer types. Because this analysis shows association rather than direction, both MIR6858-to-partner and partner-to-MIR6858 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein K63-linked ubiquitination grouped by MIR6858-low versus MIR6858-high in KIRC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR6858→partner) and Y-score (partner→MIR6858) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	Negative regulation of protein K63-linked ubiquitination →	+0.038	+0.079	<.001	<.001	3	8
READ	Protein localization to presynapse →	+0.063	+0.757	<.001	<.001	3	7
PAAD	rRNA base methylation →	+0.038	+0.145	<.001	.008	1	8
SARC	Delamination →	+0.056	+0.110	.001	.002	3	5
KIRC	Base-excision repair, AP site formation →	+0.050	+0.114	<.001	<.001	3	5
READ	Axo-dendritic protein transport →	+0.041	+0.900	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,060 associations by consensus.

Negative regulation of protein K63-linked ubiquitination by MIR6858 expression — KIRC

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