Across TCGA pan-cancer cohorts, MIR6815 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR6815’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where MIR6815 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR6815 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.
LUAD, KIRC, and LUSC are the cancer types where MIR6815 tumor–normal differential expression is most reproducible.