MIR6766

Across TCGA patient cohorts, MIR6766 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,337 significant associations in total. OV shows the largest number of these associations.

The most reproducible MIR6766-associated GO terms across cancer lineages are Negative regulation of epidermal growth factor receptor signaling pathway, Protein K63-linked ubiquitination, and Regulation of mRNA splicing, via spliceosome. Each is linked with MIR6766 in more than 6 cancer types. Because this analysis shows association rather than direction, both MIR6766-to-partner and partner-to-MIR6766 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of epidermal growth factor receptor signaling pathway grouped by MIR6766-low versus MIR6766-high in LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR6766→partner) and Y-score (partner→MIR6766) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Negative regulation of epidermal growth factor receptor signaling pathway →	+0.044	+0.075	<.001	.002	3	6
BRCA	Protein K63-linked ubiquitination →	+0.033	+0.043	<.001	<.001	3	6
SKCM	Regulation of mRNA splicing, via spliceosome →	+0.044	+0.100	.001	<.001	3	5
LUSC	Centrosome duplication →	+0.073	+0.075	<.001	.003	1	7
LUSC	UV-damage excision repair →	+0.087	+0.084	<.001	.001	3	5
LUSC	Protein deglycosylation →	+0.065	+0.061	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,337 associations by consensus.

Negative regulation of epidermal growth factor receptor signaling pathway by MIR6766 expression — LUAD

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