Across TCGA pan-cancer cohorts, MIR656 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR656’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where MIR656 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR656 is over-expressed in tumor, although a few such as BRCA and KIRP show the opposite, repressed pattern.

BRCA, KIRP, and HNSC are the cancer types where MIR656 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR656 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	−0.230	<.001	4	view →
KIRP	Male	All	−0.153	.017	2	view →
HNSC	Male	All	−0.125	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: MIR656 RNA expression & survival · all MIR656 data types