Across TCGA pan-cancer cohorts, MIR6499 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR6499’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MIR6499 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR6499 is over-expressed in tumor.
LUSC are the cancer types where MIR6499 tumor–normal differential expression is most reproducible.