Across TCGA pan-cancer cohorts, MIR627 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR627’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MIR627 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR627 is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.
KIRP and THCA are the cancer types where MIR627 tumor–normal differential expression is most reproducible.